SQUARE ONE FOUNDRY
[ PROJECTS ]

What we’ve built, and what it took.

Commissioned work, described the way an engineer would describe it. Clients are unnamed at their request; the problems, the approaches and the systems are exactly as built.

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01Portable Bioanalytical Testing InstrumentLIFE SCIENCES 02Low-Cost Consumable Analytical BiochipsCONSUMABLES 03Handheld Pupillometry Sobriety TesterMEDICAL DEVICE 04Actively Chilled, Trackable Biosample ShipperCOLD CHAIN 05Continuous Lab MonitorLAB AUTOMATION
01LIFE SCIENCES

Portable Bioanalytical Testing Instrument

THE PROBLEM

Assay-grade protein analysis lives in centralized labs on benchtop instruments. Demand for clinically meaningful data outside those labs keeps growing, but every attempt to shrink the instrument trades away the analytical rigor that made the result worth having.

WHAT WE BUILT

A deployable personal health analytics system that brings assay-grade measurement into a daily-use format — scientific-grade optics and custom analytical modules in a portable envelope, with sample handling automated so a run needs no operator technique.

Portable Bioanalytical Testing Instrument
TECHNICAL STRATEGY
•Prioritized essential capabilities from a targeted feasibility survey
•Defined the precise biochemical analysis method through rigorous literature review
•Tested and validated critical materials and components for functional reliability
HARDWARE SYSTEM
•Compact scientific-grade optics for precise measurement in a portable form
•Custom analytical modules delivering accurate protein analysis
•Automated sample handling and internal mechanics for hands-free runs
EMBEDDED SOFTWARE
•Fault-tolerant design self-monitors through user and environmental disruption
•Intelligent embedded control optimises analysis parameters in real time
•Embedded encryption keeps personal health data private and secure
02CONSUMABLES

Low-Cost Consumable Analytical Biochips

THE PROBLEM

Analytical consumables are usually constrained by whichever single material or fabrication method the developer already owns — while real applications vary enormously across sensitivity, cost, durability and scale. The chip ends up designed around the process rather than the assay.

WHAT WE BUILT

Biochip platforms developed with commercialization assumed from the outset: diverse materials and manufacturing techniques matched to each application, and programs carried from concept strategy through microfabrication and validation into pilot-scale production.

Low-Cost Consumable Analytical Biochips
FABRICATION
•Custom photolithography platforms for precision mould and mask fabrication
•Multi-material capability across resins, epoxies, silicone and glass
•Custom optical alignment systems achieving sub-5 µm accuracy
HARDWARE
•Microfluidic consumables manufactured for biological and chemical analysis
•Advanced bonding methods across diverse chip materials and geometries
•Embedded sensors for precise cellular and molecular measurement
SOFTWARE
•Real-time vision systems for live analysis inside operating biochips
•AI-driven signal processing extracting insight from unstructured chip output
•Closed-loop hardware control for stable performance during live assays
03MEDICAL DEVICE

Handheld Pupillometry Sobriety Tester

THE PROBLEM

Safety-critical industries need to judge whether an operator is fit for duty right now. The available impairment assessments are subjective, narrow, or built for a clinic — none of them survive a shift handover at a depot gate.

WHAT WE BUILT

A handheld pupil-response platform that turns neurological impairment screening into a portable, decision-oriented test: high-speed eye tracking under controlled illumination, with a result an untrained supervisor can act on immediately.

Handheld Pupillometry Sobriety Tester
TECHNICAL STRATEGY
•Validated efficacy through controlled impairment studies
•Prioritized ergonomic design for universal fit across users
•Optimized for industrial environments and reliable field performance
HARDWARE SYSTEM
•High-speed camera tracks pupil response and scleral state
•Dual light engines (infrared and white) provide controlled stimulus
•Ergonomic form ensures consistent alignment across diverse users
EMBEDDED SOFTWARE
•Real-time computer vision extracts multi-metric eye data instantly
•Intuitive interface displays immediate, actionable results
•Data encryption ensures secure, tamper-proof record storage
04COLD CHAIN

Actively Chilled, Trackable Biosample Shipper

THE PROBLEM

Conventional biosample shippers cool passively with gel packs or dry ice, so internal temperature depends on ambient conditions and drifts over long transit. Nobody knows whether a sample stayed in range until it arrives — and by then it is too late to matter.

WHAT WE BUILT

An actively chilled shipper holding 4–12 °C throughout transport: compact thermoelectric cooling under closed-loop control, combined with real-time environmental sensing and telemetry that produces a verifiable record of the whole journey.

Actively Chilled, Trackable Biosample Shipper
TECHNICAL STRATEGY
•Feasibility tests to inform custom battery-powered thermoelectric chilling
•Thermal and packaging studies optimizing insulation, layout and battery budget
•Network study to design robust telemetry for persistent in-transit connection
HARDWARE SYSTEM
•Custom thermoelectric chiller maintains stable internal temperature (4–12 °C)
•Integrated GPS, shock and orientation sensors monitor live transport conditions
•Insulated enclosure and compact internal layout minimize thermal drift
EMBEDDED SOFTWARE
•Real-time telemetry reports location and environmental metrics in transit
•Thermal controller dynamically regulates the chiller to hold target temperature
•Continuous environmental logging provides a verifiable shipment record
05LAB AUTOMATION

Continuous Lab Monitor

THE PROBLEM

A freezer that fails at 2am costs a lab its samples, and most labs find out the next morning. Existing monitoring is tied to specific equipment brands, depends on the building network staying up, and goes quiet exactly when the power does.

WHAT WE BUILT

A universally compatible environmental monitor that tracks temperature, humidity, power state and door status on any equipment, with dual-redundant cellular and WiFi alerting so a failure still reaches a human when the network or the mains does not.

Continuous Lab Monitor
TECHNICAL STRATEGY
•Equipment-agnostic sensing so one device fits any freezer, incubator or room
•Redundant alerting paths assumed from the outset, not added later
•Designed to keep reporting through mains and network loss
HARDWARE SYSTEM
•Temperature, humidity, power-state and door-status sensing in one unit
•Dual cellular and WiFi connectivity with automatic failover
•Battery-backed operation to survive power interruption
SOFTWARE
•Continuous logging with threshold and rate-of-change alerting
•Escalation to on-call staff by the path that is still available
•Dashboard history for audit and equipment-failure diagnosis
[ NOT LISTED HERE ]

Some work stays behind an NDA.

Client confidentiality is absolute — nothing proprietary leaves our hands, on a call or anywhere else. What we can do is talk through the domains we have worked in, the classes of problem we have solved and the failure modes we have seen, without touching anyone's technology.

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Square One Foundry, LLC
1111 Chastain Rd NW
Kennesaw, GA 30144